Rishu Kumari, Savita Bharat Jain, Neelima Ranjan


Introduction: Microbial keratitis is predominantly an opportunistic, serious ocular infectious disease that can lead to significant vision loss and ophthalmic morbidity.1 The fungi are significant pathogens causing ocular infections due to their frequent involvement and difficulty in establishing definitive diagnosis..

Material and Methods: We prospectively analyzed 106 cases of keratomycosis in our tertiary care hospital. Corneal scrapings were collected, processed and fungal pathogens were identified by standard laboratory techniques.

Results: Out of 106 suspected cases, culture was positive in 31 cases. Aspergillus species were the most frequent isolates (51.61%). Next to this were Candida spp. (19.35%) followed by Fusarium spp., Alternaria spp., Mucor spp , Penicillium spp, Drechslera spp and Exserohilum spp . Males were more affected than females and trauma was the most common predisposing factor.

Conclusions: This study highlights important risk factors and organisms responsible for mycotic keratitis.

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Stapleton F, Keay LJ, Sanfilippo PG, Katiyar S, Edwards KP, Naduvilath T. Relationship between climate, disease severity, and causative organism for contact lens-associated Microbial Keratitis in Australia. Am J Ophthalmol 2007; 144:690-69.

Xie L, Hu J, Shi W. Treatment failure after lamellar keratoplasty for Fungal Keratitis. Ophthalmology 2008; 115:33-6.

Abad JC, Foster CS. Fungal keratitis. Int’l Ophthalmol Clin 1996; 36: 1-15.

Thomas PA. Current perspectives on ophthalmic mycoses. Clin Microbiol Rev 2003; 16:730 97.

Verenkar MP, Subhangi B, Pinto MJW. A study of mycotic keratitis in Goa. Ind Jour of Medi Micro 1998; 16: 58-60.

Bharti MJ, Ramakrishnan R, Vasu et al. Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three year study. Indian Journal of Ophthalmology 2003; 51: 315-21.

Panda A, Sharma N, Das G, Kumar N, Satpathy G. Mycotic keratitis in children epidemiologic and microbiologic evaluation. Cornea 1997; 16: 295-9.

Srinivasan M, Ganzales CA, George C et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, South India. Brit J Ophthalmol 1997; 81: 965-71.

Tanure MA, Cohen EJ, Sudesh S, Rapuano CJ & Laibson PR. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea 2000; 19: 307–312.

Laspina F, Samudio M, Cibils D et al. Epidemiological Nepal Medical College Journal characteristic of microbiological results on patients with infectious corneal ulcers: a 13 year survey in Paraguay. Graefes Arch Clin Exp Ophthalmol 2004; 242: 204-9.

Chowdhary, Anuradha MD Spectrum of Fungal Keratitis in North India. Cornea Jan 2005;24(1):8-15.

Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and microbiological diagnosis of suppurative keratitis in gangetic West Bengal, Eastern India. Indian J Ophthalmol 2005; 53:17-22.

Kanski’s clinical ophthalmology.8th edition. Page 181.

Gopinathan U, Sharma S, Garg P, and Rao GN: Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. Indian J Ophthalmol 2009; 57: 273–279.

Nath R, Baruah S, Saikia L, Devi B, Borthakur AK, Mahanta J. Mycotic corneal ulcers in upper Assam. Indian J Ophthalmol 2001; 59: 367–371.

Thomas PA, Kaliamurthy J. Mycotic keratitis: epidemiology, diagnosis and management. Clin Microbiol Infect 2013; 19: 210–220.

Sun RL, Jones DB & Wilhelmus KR. Clinical characteristics and outcome of Candida keratitis. Am J Ophthalmol 2007; 143: 1043– 1045

Leck A K , Thomas P A , Hagan M et al. Aetiology of suppurative corneal ulcer in Ghana and South India and Epidemiology of fungal keratitis. Br J Ophthalmol 2002; 86: 1211 – 1215

Suman Saha et al. epidemiological profile of fungal keratitis in urban population of West Bengal,India. Oman Journal of Ophthalmology 2009;2(3):114-118

Varsha Tukaram Kalshetti, Surendra P. Wadgaonkar , Viraj M. Bhate, Rahul G. Wadile , Neha Haswani , S.T. Bothikar. Microbiological evaluation of mycotic keratitis in north Maharashtra, India: A prospective study. Journal of Microbiology and Infectious Diseases 2015; 5 (3): 99-102.

Chander J, Singla N et al. Keratomycosis in and around Chandigarh. A five-year study from North Indian tertiary care hospital. Indian Jour of Pathol and Microbiol 2008; 51 (2): 304-6.

Khanal B, Deb M Panda A et al Laboratory diagnosis in ulcerative keratitis. Int journal in Experimental and clinical Ophthal; 2005; 37(3); 123-7.

Xie L et al. Spectrum of fungal keratitis in north China. Ophthalmology. 2006 Nov; 113(11):1943-8. Epub 2006 Aug 28.

Prashant Garg, Usha Gopinathan, Kushal Choudry et al, Keratomycosis: Clinical and microbiologic experience with Dematiaceous fungi. Ophthal 2007; 107;574-80.

Nath R, Barwah S, Saikia L, Devi B, Borthakur et al. Myoctic corneal ulcer in upper Assam. Indian J Ophthalmol 2011; 59:367-71.

Namrata Kumari, A Xess, S K Shahi. A study of keratomycosis: one experience. Indian journal of Mico & Path 2002; 45(3) 299-302.

Deshpande, S D, Koppikar, G.V.1999. A study of mycotic keratitis in Mumbai.IJMM 1999; 42(1):81-87.

Mallareddy US, Katay P, Anke G. A study of fungal etiology of infective keratitis. Int J Currr Microbiol App Sci 2015; 4(8):664-670.


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