ANTIOXIDANT EFFECT OF SCOPARIA DULCIS LINN. ETHANOL EXTRACT ( IN VITRO STUDY

P. K. Valsalakumari, Dr.S. Kumaran

Abstract


Scoparia dulcis, Linn., an indigenous herbal plant used traditionally in Ayurvedic medicine, in India, for its possible anti ulcer, urolithiasis1, antidiabetic  and antimicrobial activities. An aqueous extract of the plant showed marked antioxidative activity in vitro, which supports the therapeutic effects claimed by traditional practitioners for its antidiabetic activity. The annual herb is belongs to the family Scrophulariaceae and distributed throughout the tropics. The present study is aimed to investigate the anti oxidant activity of ethanol extract of dried whole plant, Scoparia dulcis collected from south region of Tamil Nadu state, India. The plant is here and after referred as S.dulcis and the ethanol extract as EESD. A stock solution of the extract 1mg/ml was prepared. Then aliquate dilutions of 125, 250, 500 and 1000 and 2000 µg/ ml were prepared from the stock for studying the in vitro anti oxidant activity.

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References


Anju Mathew, Malar Retna. Antilithiatic activity and Pharmacognostic studies of Scoparia dulcis, Research Articles. Home/ Archives. 2016 Jan; Vol 2 (1).

Ahmed, M., H.A. Shikha, S.K. Sadhu, M.T. Rahman and B.K. Datta, 2001. Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis. Pharmazie, 56: 657-660

Chow, S.Y., S.M. Chen, C.M. Yang and H. Hsu, 1974. Pharmacological studies on Chinese herbs. Hypotensive effects of 30 Chinese herbs. Taiwan Yi Xue Hui Za Zhi., 73: 729-739

De Farias Freire, S.M., J.A. da Silva Emim, A.J. Lapa, C. Souccar and L.M.B. Torres, 1993. Analgesic and antiinflammatory properties of Scoparia dulcis L. extract and glutinol in rodents. Phytother. Res., 7: 408-414.

International Journal of Scientific and Research Publications, Volume 4, Issue 12, Dec. 2014 1,ISSN 2250-3153

Chang, S. T., Wu, J.-H., Wang, S.-Y., Kang, P.-L., Yang, N.-S., &Shyur, L.-F.

Antioxidant activity of extracts from Acacia confusa bark and heartwood. J ofAgricultural and Food Chem 2001; 49: 3420–3424.

Tsai JC , Peng WH , Chiu TH , Lai SC , Lee CY. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. The American Journal of Chinese Medicine 2011, 39(5):943-956.

Nath, M.C., 1943. Investigations on the new antidiabetic principle (amellin) occurring in nature. Part I. Studies on some of its biochemical properties. Ann. Biochem. Exp. Med., 3: 55-62.

Ratnasooriya WD , Jayakody JR , Premakumara GA , Ediriweera ER. Antioxidant activity of water extract of Scoparia dulcis. Fitoterapia 2005., 76(2):220-222.

Jain, H.C, Indian plants with oral hypoglycaemic activity. Proceedings of the Abstract International Research Congress National Product College Pharmacology University North Carolina, 1985. July 7-12.

Ang Zhang, Yulin Fang, Hua Wang, Hua Li and Zhenwen Zhang. Free-Radical Scavenging Properties and Reducing Power of Grape Cane Extracts from 11 Selected Grape Cultivars Widely Grown in China. Molecules 2011., 16: 10104-10122.

Coulibaly AY , Kiendrebeogo M , Kehoe PG , Sombie PA , Lamien CE , Millogo JF , Nacoulma OG. Antioxidant and anti-inflammatory effects of Scoparia dulcis L. Journal of Medicinal Food .,2011, 14(12):1576-1582.

Francis M. Awah1 and Andrew W. Verla. Antioxidant activity, nitric oxide scavenging activity and phenolic contents of Ocimum gratissimum leaf extract . J. Med. Plant. Res. 2010., Vol. 4(24), 2479-2487.

Hasant A, Zulfiker M, Ripa FA, Rahman MM, Ullah OM, Hamid K, et al. Antidiabetic and antioxidant effect of Scoparia dulcis in alloxan induced albino rats. Int Res 2010; 2(4):2527-34.

LangeswaranK Jagadeesan A.J, Vijayaprakash S,Balasubramanian M.P. Hepatoprotective and Antioxidant activity of Scoparia dulcis Linn, against N Nitrosodiethylamine (DEN) induced Hepatotoxicity in experimental Rats.International Journal of Drug Development and Research. ISSN: 0975- 9344.

Mishra A , Pradhan DK , Panda AK , Behera RK , Jha S. Antidiabetic and Antioxidant Activity of Scoparia dulcis Linn. Indian Journal of Pharmaceutical Sciences., 2013., 75(5):610-614.


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