Jayashree Nadkarni, Sneha Dasgupta, Debashish Biswas


Late onset HDN can present as bleeding from any site of the body but more commonly from intracranial vessels. It is diagnosed if bleeding occurs after 7th day of life with normal platelet count, prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), associated with stopping of bleeding and PT/PTT returning to normal after giving vitamin K. Among the types of intracranial bleeding in late hemorrhagic disease of newborn, intracerebral parenchymal bleeding is least common.

Full Text:



Vitamin K Ad Hoc Task Force. Controversies concerning vitamin K and the

newborn. Pediatrics 1993; 91: 1001-1003.

Isarangkura PB, Pintadit P, Tejavej A, Siripoonya P. Chulajata C, Green GM.

Vitamin K prophylaxis in the neonate by oral route and its significance in

reducing infant mortality and morbidity. J Med Assoc Thai 1986; 69: 56-61.

Ijland MM, Pereira RR, Cornelissen EA. Incidence of late vitamin K

deficiency bleeding in new-borns in the Netherlands in 2005: Evaluation of the

current guideline. Eur J Paediatr 2008; 167: 165-169.

Waseem M. Vitamin K and hemorrhagic disease of new-borns. South Med J

; 99: 1199.

Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr 1985; 106: 351-359.

Singh M. Vitamin K during infancy: Current status and recommendations.

Indian Pediatr 1997; 34: 708-712.

Bor O, Akgun N, Yakut A, et al. Late hemorrhagic disease of the new-born.

Paediatr Int 2000; 42: 64-66.

D?Souza IE, Rao SD. Late hemorrhagic disease of new-born. Indian Paediatr

; 40: 226-229.

Flood VH, Galderisi FC, Lowas SR, et al. Hemorrhagic disease of the new-born

despite vitamin K prophylaxis at birth. Paediatr Blood Cancer 2008; 50: 1075-

Zengin E, Sarper N, Türker G, et al. Late haemorrhagic disease of the new-

born. Ann Trop Paediatr 2006; 26: 225-231.

Sutor AH, Dagres N, Niederhoff H. Late form of vitamin K deficiency

bleeding in Germany. KlinPediatr 1995; 207: 89-97.


  • There are currently no refbacks.