HEPATOBLASTOMA- MULTIMODALITY TREATMENT AND OUTCOMES - A TERTIARY CENTRE EXPERIENCE

Dr Vikas Warikoo, Dr Nikhil Garg

Abstract


Hepatoblastoma (HBL) is the most common primary liver tumor in
children and accounts for 1% of all pediatric cancers(1). Preterm is a risk
factor although most cases are sporadic, but some are associated with
constitutional genetic abnormalities and malformations, such as the
Beckwith-Wiedemann syndrome and familial adenomatous polyposis
( 2 , 3 ) . Over the last three decades, the annual incidence of
Hepatoblastoma in children has gradually increased(4). Extremely
premature babies with a low birth weight have been reported to have a
greatly increased risk of developing Hepatoblastoma. The increased
survival rates of these premature babies might account for the
increased annual incidence of Hepatoblastomas. Upto 60% of
hepatoblastoma are unresectable on presentation( 5 ) .Due to
chemoresponsiveness of hepatoblastoma neoadjuvant chemotherapy
is used to downsize the tumor for surgical resection. This retrospective
study reviews our experience with multimodality treatment in
management of hepatoblastoma.


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References


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